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Image Search Results
Journal: Theranostics
Article Title: Inhibition of Th17 cells by donepezil ameliorates experimental lung fibrosis and pulmonary hypertension.
doi: 10.7150/thno.82069
Figure Lengend Snippet: Figure 3. DON ameliorates lung fibrosis in BLM-induced mice by inhibiting fibroblast activation. A. Representative immunofluorescent staining with αSMA for lung tissue (×200 magnification). B. Representative protein levels in lung tissue. C~E. Statistical analysis of the levels of collagen I, collagen III, and αSMA in lung tissue (n = 8). F. Representative protein levels in lung fibroblasts. G~I. Quantitative analysis of the levels of collagen I, collagen III, and αSMA in lung fibroblasts (n = 4). J: Representative immunofluorescent staining with collagen I and αSMA for fibroblasts (×200 magnification). αSMA: alpha-smooth muscle actin, BLM: bleomycin, Ctrl: control, Col1: collagen I, Col3: collagen III, DON: donepezil. *P < 0.05, versus Ctrl group, #P < 0.05, versus BLM group.
Article Snippet: To further verify the effect of IL17A on
Techniques: Activation Assay, Staining, Control
Journal: Theranostics
Article Title: Inhibition of Th17 cells by donepezil ameliorates experimental lung fibrosis and pulmonary hypertension.
doi: 10.7150/thno.82069
Figure Lengend Snippet: Figure 6. Th17 cell stimulates lung fibroblasts by secreting IL17A. A. Diagrammatic sketch of the co-cultivation of Th17 cells and lung fibroblasts. B. Representative protein levels in lung fibroblasts after co-cultivation. C~E. Statistical analysis of the expression of collagen I, collagen III, and αSMA in lung fibroblasts after co-cultivation (n = 4). F. Representative immunofluorescent staining for collagen I and αSMA (×200 magnification). G. Quantitative analysis of IL17A concentration in the co-culture medium (n = 5). H. The level of IL17RA in lung fibroblasts after co-cultivation (n = 4). αSMA: alpha-smooth muscle actin, Ctrl: control, Col1: collagen I, Col3: collagen III, IL17A: interleukin 17A, IL17RA: interleukin 17A receptor, Th17: T helper 17. *P < 0.05, versus Ctrl group, &P < 0.05, versus Th17 cell group.
Article Snippet: To further verify the effect of IL17A on
Techniques: Expressing, Staining, Concentration Assay, Co-Culture Assay, Control